Structure of PDB 7rhq Chain C Binding Site BS02

Receptor Information
>7rhq Chain C (length=171) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERF
KELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLR
VTEGWDEHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYE
SKAHIHCSVKAENSVAAKSGG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7rhq Chain C Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7rhq Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		E90 E126 D129
Binding residue
(residue number reindexed from 1)		E67 E103 D106
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:7rhq, PDBe:7rhq, PDBj:7rhq
PDBsum7rhq
PubMed35231446
UniProtQ15465|SHH_HUMAN Sonic hedgehog protein (Gene Name=SHH)

[Back to BioLiP]