Structure of PDB 7qtl Chain C Binding Site BS02

Receptor Information
>7qtl Chain C (length=726) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM
MAMKYPITADKRIMEMIPERNEQGQTLWSKTNSDRVMVSPLAVTWWNRNG
PTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHAD
LSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKKELQDCKIAPLMV
AYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRND
DVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVDILRQNPT
EEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLK
IRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGKDEQSIAEAIIVAMV
FSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEP
IDNVMGMIGILPDMTPSTEMSLRGVRVSKMERVVVSIDRFLRVRDQRGNV
LLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWENVK
IQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRVLFQQMRDVLGTFD
TVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRIVVRGNSPVFNYNKA
TKRLTVLGKDAGALMEDPDEGTAGVESAVLRGFLILGKENKRYGPALSIN
ELSNLAKGEKANVLIGQGDVVLVMKR
Ligand information
Receptor-Ligand Complex Structure
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PDB7qtl Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.48 Å
Binding residue
(original residue number in PDB)		K33 P43 R144 K157 R213 Q257 N422 R423 H432 R436 K440
Binding residue
(residue number reindexed from 1)		K33 P43 R141 K154 R210 Q254 N419 R420 H429 R433 K437
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0033650 host cell mitochondrion
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qtl, PDBe:7qtl, PDBj:7qtl
PDBsum7qtl
PubMed36596301
UniProtX5F427

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