Structure of PDB 7qhm Chain C Binding Site BS02

Receptor Information
>7qhm Chain C (length=233) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDQALISEGKDLYDVACITCHGVNLQGVEDRGPSLVGVGEGAVYFQVHSG
RMPILRNEAQAERKAPRYTEAQTLAIAAYVAANGGGPGLVYNEDGTLAME
ELRGENYDGQITSADVARGGDLFRLNCASCHNFTGRGGALSSGKYAPNLD
AANEQEIYQAMLTGPQNMPKFSDRQLSADEKKDIIAFIKSTKETPSPGGY
SLGSLGPVAEGLFMWVFGILVLVAAAMWIGSRS
Ligand information
Ligand IDHEC
InChIInChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,9-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;+4/b21-7?,22-8?,26-13-,29-14-,30-15-,31-16-;
InChIKeyHXQIYSLZKNYNMH-LJNAALQVSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)CCC1=C(C2=CC6=C(C(=C/C)\C5=CC4=C(C(\C3=Cc7c(c(c8C=C1N2[Fe](N34)(N56)n78)CCC(=O)O)C)=C/C)C)C)C
OpenEye OEToolkits 1.5.0CC=C1C(=C2C=C3C(=CC)C(=C4N3[Fe]56N2C1=Cc7n5c(c(c7C)CCC(=O)O)C=C8N6C(=C4)C(=C8CCC(=O)O)C)C)C
CACTVS 3.341C\C=C1/C(=C2C=C3N4C(=Cc5n6c(C=C7N8C(=C(C)\C7=C/C)C=C1N2[Fe@@]468)c(C)c5CCC(O)=O)C(=C3C)CCC(O)=O)C
CACTVS 3.341CC=C1C(=C2C=C3N4C(=Cc5n6c(C=C7N8C(=C(C)C7=CC)C=C1N2[Fe]468)c(C)c5CCC(O)=O)C(=C3C)CCC(O)=O)C
FormulaC34 H34 Fe N4 O4
NameHEME C
ChEMBL
DrugBank
ZINC
PDB chain7qhm Chain C Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7qhm Structural basis for safe and efficient energy conversion in a respiratory supercomplex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		F95 R101 R113 C177 C180 H181 P197 L199 A210 M211 P215 Q216 M218 P219 F221
Binding residue
(residue number reindexed from 1)		F45 R51 R63 C127 C130 H131 P147 L149 A160 M161 P165 Q166 M168 P169 F171
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.8: quinol--cytochrome-c reductase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qhm, PDBe:7qhm, PDBj:7qhm
PDBsum7qhm
PubMed35087070
UniProtQ8NNK5|QCRC_CORGL Cytochrome bc1 complex cytochrome c subunit (Gene Name=qcrC)

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