Structure of PDB 7pw5 Chain C Binding Site BS02

Receptor Information
>7pw5 Chain C (length=310) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSM
VMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLD
TQPILSPSILDHLINNYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFT
DLSLYRFLQTAEMVKPSTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQ
LMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDPLFSLLPG
YRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKS
SALAEYSRLL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7pw5 Chain C Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7pw5 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		S218 T253
Binding residue
(residue number reindexed from 1)		S49 T84
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0007420 brain development
GO:0007507 heart development
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pw5, PDBe:7pw5, PDBj:7pw5
PDBsum7pw5
PubMed34698635
UniProtQ9H0W8|SMG9_HUMAN Nonsense-mediated mRNA decay factor SMG9 (Gene Name=SMG9)

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