Structure of PDB 7of2 Chain C Binding Site BS02

Receptor Information
>7of2 Chain C (length=401) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTQRVCLVHPDVWQVAEATALVHTLDGWSVVQTMVVSTKTPDRKLIFGKG
NFEHLTEKIRGSPDITCVFLNVERMAAPTKKELEAAWGVEVFDRFTVVLH
IFRCNARTKEARLQVALAEMPLHRSNLKRDVAHLYRGVGSRYIMGSGESF
MQLQQRLLREKEAKIRKALDRLRKKRHLLRRQRTRREFPVISVVGYTNCG
KTTLIKALTGDAAIQPRDQLFATLDVTAHAGTLPSRMTVLYVDTIGFLSQ
LPHGLIESFSATLEDVAHSDLILHVRDVSHPEAELQKCSVLSTLRGLQLP
APLLDSMVEVHNKVDLVNVVPVSALRGHGLQELKAELDAAVLKATGRQIL
TLRVRLAGAQLSWLYKEATVQEVDVIPEDGAADVRVIISNSAYGKFRKLF
P
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain7of2 Chain C Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7of2 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		T303 N304 G306 K307 T308 T309 P322 R323 F327 A328 T329 N418 K419 D421 L422 S437 A438 L439
Binding residue
(residue number reindexed from 1)		T197 N198 G200 K201 T202 T203 P216 R217 F221 A222 T223 N312 K313 D315 L316 S323 A324 L325
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005525 GTP binding
GO:0043022 ribosome binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7of2, PDBe:7of2, PDBj:7of2
PDBsum7of2
PubMed34135319
UniProtO43824|GTPB6_HUMAN Putative GTP-binding protein 6 (Gene Name=GTPBP6)

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