Structure of PDB 7mib Chain C Binding Site BS02

Receptor Information
>7mib Chain C (length=554) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGSIPLIPVRMLNEHVYCPRLAYLMWVQGEFSHNEFTVDGVIRHRRVDAG
GGVLPSETQEDSRIHARSVSLSSERLGITAKIDLVEGEGAYVSPVDYKRG
KRPHVAGGAYEPERVQLCAQGLLLREHGFASDGGALYFVASRERVPVAFD
DELIGRTLAAIDEMGRTALSGTMPPPLEDSPKCPRCSLVGICLPDEVRFL
SHLSVEPRPIIPADGRGLPLYVQSPKAYVRKDGDCLVIEEERVRVAEARL
GETSQVALFGNATLTTAALHECLRREIPVTWLSYGGWFMGHTVSTGHRNV
ETRTYQYQRSFDPETCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPP
GLLMSLQDDMRHAMRAPSLEVLLGIEGASAGRYFQHFSRMLRGGDGEGMG
FDFTTRNRRPPKDPVNALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPR
FGRPALALDMMEPFRPLIADSTVLMAINNGEIRTGDFVRSAGGCNLTDSA
RKRFIAGFERRMEQEVTHPIFKYTISYRRLLEVQARLLTRYLSGEIPAYP
NFVT
Ligand information
>7mib Chain H (length=64) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctgtgccgtccgtaacgttgtcgatttttgtattccggggccatgatgcc
ccggcctcattgaa
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mib Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Resolution5.8 Å
Binding residue
(original residue number in PDB)		K235 D236 G237 T269 A271 P354 L357 M358 Q361 R365
Binding residue
(residue number reindexed from 1)		K231 D232 G233 T265 A267 P350 L353 M354 Q357 R361
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7mib, PDBe:7mib, PDBj:7mib
PDBsum7mib
PubMed34588691
UniProtQ74H36|CS4F1_GEOSL CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion (Gene Name=cas4-cas1)

[Back to BioLiP]