Structure of PDB 7lrc Chain C Binding Site BS02

Receptor Information

>7lrc Chain C (length=371) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRL
FEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLT
TQPIPGLSTVGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYD
HPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINL
DHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRL
LVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPF
MDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVERKIYCQITQHL
LQNHKMWKKVIEEEQRLAGIE

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

7lrc Chain C Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lrc Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Resolution	2.97 Å
Binding residue (original residue number in PDB)	H756 H836 D837 D950
Binding residue (residue number reindexed from 1)	H88 H147 D148 D261
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.

Gene Ontology

	Molecular Function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081	phosphoric diester hydrolase activity

	Biological Process
GO:0007165	signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:7lrc, PDBe:7lrc, PDBj:7lrc
PDBsum	7lrc
PubMed	34272366
UniProt	Q14432\|PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Gene Name=PDE3A)

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