Structure of PDB 7lf4 Chain C Binding Site BS02

Receptor Information

>7lf4 Chain C (length=416) Species: 9606 (Homo sapiens)

SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFFSS

Ligand information

>7lf4 Chain F (length=11) Species: 9606 (Homo sapiens)

EVQRKRQKLMP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lf4 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): R96 K97 S100 S101 W137 N141 S144 G145 W179 N183 N219 W222 N226 R229
• Binding residue (residue number reindexed from 1): R25 K26 S29 S30 W66 N70 S73 G74 W108 N112 N148 W151 N155 R158

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008139 nuclear localization sequence binding
• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus
• GO:0006607 NLS-bearing protein import into nucleus
• GO:0010467 gene expression
• GO:0014046 dopamine secretion
• GO:0015031 protein transport

Cellular Component

• GO:0005634 nucleus
• GO:0005643 nuclear pore
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0031965 nuclear membrane
• GO:0042564 NLS-dependent protein nuclear import complex

External links

• PDB: RCSB:7lf4, PDBe:7lf4, PDBj:7lf4
• PDBsum: 7lf4
• PubMed: 35260573
• UniProt: O00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)