Structure of PDB 7kso Chain C Binding Site BS02

Receptor Information
>7kso Chain C (length=420) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNI
KRKTFKVDDMLSKVEKMKGAHLQLTFTGFFHKVTLEVLLVKVCHKKRKDV
SCPIRQVPTGKKQVPLNSLAVSSNEFEPSNSHMVKSYSLLFRVTRFVAQM
TVFDKNRRLQLLDGEYEVAMQEMGPTLQFTLRWRIFYQFLYNNNTRQQTE
ARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPARIDVSINECY
DGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPRTYSSGHNRLYF
HSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKL
WNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDF
NLISIMSIDKAVTKLREMQQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7kso Chain C Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kso Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		C453 H466 H471
Binding residue
(residue number reindexed from 1)		C210 H223 H228
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 transcription corepressor binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0031490 chromatin DNA binding
GO:0035064 methylated histone binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0106222 lncRNA binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0045596 negative regulation of cell differentiation
GO:0048709 oligodendrocyte differentiation
GO:0060816 random inactivation of X chromosome
GO:0140718 facultative heterochromatin formation
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005730 nucleolus
GO:0016586 RSC-type complex
GO:0016604 nuclear body
GO:0032993 protein-DNA complex
GO:0035098 ESC/E(Z) complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kso, PDBe:7kso, PDBj:7kso
PDBsum7kso
PubMed33514705
UniProtQ15022|SUZ12_HUMAN Polycomb protein SUZ12 (Gene Name=SUZ12)

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