Structure of PDB 7jtn Chain C Binding Site BS02

Receptor Information
>7jtn Chain C (length=702) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWS
TLKTKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYT
LRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDS
VTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLS
SLTETIKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVA
SYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEGTNTKK
ALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRD
LLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKD
MENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKG
HESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHP
NYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRAL
RLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCE
RDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHK
RSRFIQVGVISWGVVDVCKNQVPAHARDFHINLFQVLPWLKEKLQDEDLG
FL
Ligand information
>7jtn Chain D (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcugagaauagaaguaggaguaugcuugcu
<<..<<..................>>.>>.
Receptor-Ligand Complex Structure
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PDB7jtn Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		V46 T48 T50 R52 S53 S58 T59 K61 T62 R168 S196 L408 N410
Binding residue
(residue number reindexed from 1)		V38 T40 T42 R44 S45 S50 T51 K53 T54 R157 S185 L376 N378
Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jtn, PDBe:7jtn, PDBj:7jtn
PDBsum7jtn
PubMed33419768
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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