Structure of PDB 7e5e Chain C Binding Site BS02

Receptor Information
>7e5e Chain C (length=332) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RATHRLLLLGAGESGKSTIVKQMRILHVNGFNGKATKVQDIKNNLKEAIE
TIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALW
EDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLT
SGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYN
MVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAG
KSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTAHYC
YPHFTCAVDTENIRRVFNDCRDIIQRMHLRQY
Ligand information
>7e5e Chain G (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YLITFRQWAFNLPCG
Receptor-Ligand Complex Structure
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PDB7e5e State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		L46 R228 D229 E230 R231 W234 I257 E268 N271 L272 S275 I276
Binding residue
(residue number reindexed from 1)		L9 R174 D175 E176 R177 W180 I203 E214 N217 L218 S221 I222
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7e5e, PDBe:7e5e, PDBj:7e5e
PDBsum7e5e
PubMed36170854
UniProtP63092|GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gene Name=GNAS)

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