Structure of PDB 7a24 Chain C Binding Site BS02

Receptor Information
>7a24 Chain C (length=693) Species: 3712 (Brassica oleracea) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTQILPPRNPVGGARVHFSNPEDAIEVFVDGYAVKVPKGFTVLQACEVAG
VDIPRFCYHSRLSIAGNCRMCLVEVEKSPKPVASCAMPALPGMKIKTDTP
IAKKAREGVMEFLLMNHPLDCPICDQGGECDLQDQSMAFGSDRGRFTEMK
RSVVDKNLGPLVKTVMTRCIQCTRCVRFASEVAGVQDLGILGRGSGEEIG
TYVEKLMTSELSGNVIDICPVGALTSKPFAFKARNWELKATETIDVSDAV
GSNIRVDSRGPEVMRIIPRLNEDINEEWISDKTRFCYDGLKRQRLSDPMI
RDSDGRFKAVSWRDALAVVGDIIHQVKPDEIVGVAGQLSDAESMMVLKDF
VNRMGSDNVWCEGTAAGVDADLRYSYLMNTSISGLENADLFLLIGTQPRV
EAAMVNARICKTVRASNAKVGYVGPPAEFNYDCKHLGTGPDTLKEIAEGR
HPFCTALKNAKNPAIIVGAGLFNRTDKNAILSSVESIAQANNVVRPDWNG
LNFLLQYAAQAAALDLGLIQQSAKALESAKFVYLMGADDVNVDKIPKDAF
VVYQGHHGDKAVYRANVILPASAFTEKEGTYENTEGFTQQTVPAVPTVGD
ARDDWKIVRALSEVSGVKLPYNSIEGVRSRIKSVAPNLVHTDEREPAAFG
PSLKPECKEAMSTTPFQTVVENFYMTNSITRASKIMAQCSAVL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7a24 Chain C Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a24 Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		C218 I219 Q220 C221 T222 R223 C224 I248 C268 P269
Binding residue
(residue number reindexed from 1)		C169 I170 Q171 C172 T173 R174 C175 I199 C219 P220
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009853 photorespiration
GO:0042773 ATP synthesis coupled electron transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0009507 chloroplast
GO:0009536 plastid
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045271 respiratory chain complex I

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a24, PDBe:7a24, PDBj:7a24
PDBsum7a24
PubMed33060577
UniProtQ9FGI6|NDUS1_ARATH NADH dehydrogenase [ubiquinone] iron-sulfur protein 1, mitochondrial (Gene Name=EMB1467)

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