Structure of PDB 6zpi Chain C Binding Site BS02

Receptor Information
>6zpi Chain C (length=332) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GDAIKVFVRIRPPAEQNLSLSVLSSTSLRLHSNPEPKTFTFDHVADVDTT
QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESFSHNLR
GVIPRSFEYLFSLIDREKEGKSFLSKCSFIEIYNEQIYDLLDSASAGLYL
REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSH
AVFTITIESMEKVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRS
LSTLGQVITALVDVGNGKQRHVSYRDSKLTFLLRDSLGGNAKTAIIANVH
PGSRSFGETLSTLNFAQRAKLIKNKAVVNEDT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6zpi Chain C Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6zpi The mechanism of kinesin inhibition by kinesin-binding protein.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		T116 S234
Binding residue
(residue number reindexed from 1)		T85 S197
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6zpi, PDBe:6zpi, PDBj:6zpi
PDBsum6zpi
PubMed33252036
UniProtQ9NS87|KIF15_HUMAN Kinesin-like protein KIF15 (Gene Name=KIF15)

[Back to BioLiP]