Structure of PDB 6y88 Chain C Binding Site BS02

Receptor Information
>6y88 Chain C (length=264) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERA
KRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDF
FQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALD
DVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTF
EVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFM
RADDPGLELKRLFF
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain6y88 Chain C Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6y88 Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa : Decarboxylation is not essential for indole formation.
Resolution2.09983 Å
Binding residue
(original residue number in PDB)		K14 R21 R122 D124 Q131 E134
Binding residue
(residue number reindexed from 1)		K13 R20 R121 D123 Q130 E133
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E61 K63 K123 E172 N194 E224 S225
Catalytic site (residue number reindexed from 1) E60 K62 K122 E171 N193 E223 S224
Enzyme Commision number 4.1.1.48: indole-3-glycerol-phosphate synthase.
Gene Ontology
Molecular Function
GO:0004425 indole-3-glycerol-phosphate synthase activity
GO:0004640 phosphoribosylanthranilate isomerase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6y88, PDBe:6y88, PDBj:6y88
PDBsum6y88
PubMed32928960
UniProtP20577|TRPC_PSEAE Indole-3-glycerol phosphate synthase (Gene Name=trpC)

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