Structure of PDB 6wzb Chain C Binding Site BS02

Receptor Information
>6wzb Chain C (length=411) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLK
MLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMAR
LFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTI
FFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYA
PIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYG
IDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPL
GATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGV
PGAGAIMLAMVLESVGLPLTDPNVAAAYAMILCIDAILDMGRTMVNVTGD
LTGTAIVAKTE
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain6wzb Chain C Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wzb Glutamate transporters have a chloride channel with two hydrophobic gates.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		T308 I309 M311 S349 I350 G351 T352
Binding residue
(residue number reindexed from 1)		T303 I304 M306 S344 I345 G346 T347
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wzb, PDBe:6wzb, PDBj:6wzb
PDBsum6wzb
PubMed33597752
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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