Structure of PDB 6uro Chain C Binding Site BS02

Receptor Information

>6uro Chain C (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACG
KGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYS
KFGECSNKECPFLHID

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

6uro Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	6uro Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	C41 H59
Binding residue (residue number reindexed from 1)	C41 H59
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding
GO:1990837	sequence-specific double-stranded DNA binding

	Biological Process
GO:0006397	mRNA processing

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
GO:0043231	intracellular membrane-bounded organelle

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Cellular Component

External links

PDB	RCSB:6uro, PDBe:6uro, PDBj:6uro
PDBsum	6uro
PubMed	31810758
UniProt	O95639\|CPSF4_HUMAN Cleavage and polyadenylation specificity factor subunit 4 (Gene Name=CPSF4)

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