Structure of PDB 6u6x Chain C Binding Site BS02
Receptor Information
>6u6x Chain C (length=376) Species:
9606
(Homo sapiens) [
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TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPRPENKSFLYEIVSNIDVAKWDYFARDCHHLGIQNNFDY
KRFIKFARVCEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKAD
DYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREI
LKQIEYRNLFKYVGETQPIKREDYESLPKEVASAAEDFIVDVINQLIRVY
CKKVDRKSLYAARQYFVQWCADRNFT
Ligand information
>6u6x Chain F (length=4) [
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cgcc
Receptor-Ligand Complex Structure
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PDB
6u6x
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Resolution
2.58 Å
Binding residue
(original residue number in PDB)
Y155 V156 R371 R372 H376 K377 R451
Binding residue
(residue number reindexed from 1)
Y42 V43 R227 R228 H232 K233 R307
Enzymatic activity
Enzyme Commision number
3.1.5.-
External links
PDB
RCSB:6u6x
,
PDBe:6u6x
,
PDBj:6u6x
PDBsum
6u6x
PubMed
33531504
UniProt
Q9Y3Z3
|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)
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