Structure of PDB 6tw1 Chain C Binding Site BS02

Receptor Information

>6tw1 Chain C (length=740) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SGMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMK
WMMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTW
WNRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDIN
PGHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKI
SPIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPGG
EAENDDLDQTLIIASRNIVRRSIVAIDPLASLLSMCHTTSISSEPLVEIL
RSNPTDEQAVNICKAALGIRINNSFSFGGYNFKRVKGSSQRTEKAVLTGN
LQTLTMTIFEGYEEFNVSGKRASAVLKKGAQRLIQAIIGGRTLEDILNLM
ITLMVFSQEEKMLKAVRGDLNFVNRANQRLNPMYQLLRHFQKDSSTLLKN
WGTEEIDPIMGIAGIMPDGTINKTQTLMGVRLSQGGVDEYSFNERIRVNI
DKYLRVRNEKGELLISPEEVSEAQGQEKLPINYNSSLMWEVNGPESILTN
TYHWIIKNWELLKTQWMTDPTVLYNRIEFEPFQTLIPKGNRAIYSGFTRT
LFQQMRDVEGTFDSIQIIKLLPFSAHPPSLGRTQFSSFTLNIRGAPLRLL
IRGNSQVFNYNQMENVIIVLGKSVGSPERSILTESSSIESAVLRGFLILG
KANSKYGPVLTIGELDKLGRGEKANVLIGQGDTVLVMKRK

Ligand information

>6tw1 Chain M (length=10)

acggacacau

..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6tw1 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): P43 Y205
• Binding residue (residue number reindexed from 1): P45 Y207

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:6tw1, PDBe:6tw1, PDBj:6tw1
• PDBsum: 6tw1
• PubMed: 32304664
• UniProt: H6QM90