Structure of PDB 6teo Chain C Binding Site BS02

Receptor Information
>6teo Chain C (length=867) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTIFTQLKKNIPKTRYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMDL
LVIDSHKRIPDMSKNVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTD
LESKSRMINFLDAPGHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQL
IKQSIKNNVAMCFVINKLDRLILDLKLPPMDAYLKLNHIIANINSFTKGN
VFSPIDNNIIFASTKLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSV
YYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRS
NFRVNLSQEALQYDPQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNK
TAHLSIPGKSTPEGTLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRIL
DTSQSESRQKRQLHDISDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLI
KGISSAYIKSATLYSVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRE
LPKLLDALNKISKYYPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYA
KIEIKISDPLTVFSESCSNESFASIPGLSISVAAEPMDSKMIQDLSRNTL
GKNCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLP
DEISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVN
IDVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELM
KKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQL
YFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRDGPTLEK
YISAELYAQLRENGLVP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6teo Chain C Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6teo A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T147 S190
Binding residue
(residue number reindexed from 1)		T45 S88
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000349 generation of catalytic spliceosome for first transesterification step
GO:0000387 spliceosomal snRNP assembly
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6teo, PDBe:6teo, PDBj:6teo
PDBsum6teo
PubMed32196113
UniProtP36048|SN114_YEAST Pre-mRNA-splicing factor SNU114 (Gene Name=SNU114)

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