Structure of PDB 6tc9 Chain C Binding Site BS02

Receptor Information

>6tc9 Chain C (length=259) Species: 996307 (Neisseria meningitidis alpha522)

PELPEVETTLRGIAPHIEGKTVEAVVLRQLKLRWQINPDLGEILSGRQVL
SCGRRAKYLLIRFQTGVLLIHLGMSGSLRIFTPSDGRIGRPDRHDHVDIV
FSDGTVMRYRDPRKFGAILWYEEEHHPLLEKLGPEPLSEAFCADYLYARL
KAQKRAVKLALMDNAVVVGVGNIYANESLFRAGISPHRPANRLKKKECAL
LVETVKAVLQRAIETGSGYFQQEYTVYGRHNQPCPRCGGLVVKETLGQRG
TFYCPNCQK

Ligand information

>6tc9 Chain F (length=14)

aggtagacctggac

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6tc9 Conformational changes of DNA repair glycosylase MutM triggered by DNA binding.
• Resolution: 2.175 Å
• Binding residue (original residue number in PDB): H95 P113 R114 K115 F116
• Binding residue (residue number reindexed from 1): H94 P112 R113 K114 F115

Enzymatic activity

• Enzyme Commision number: 3.2.2.23: DNA-formamidopyrimidine glycosylase.
  4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
• GO:0008270 zinc ion binding
• GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
• GO:0016787 hydrolase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
• GO:0016829 lyase activity
• GO:0019104 DNA N-glycosylase activity
• GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
• GO:0046872 metal ion binding
• GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Biological Process

• GO:0006281 DNA repair
• GO:0006284 base-excision repair

External links

• PDB: RCSB:6tc9, PDBe:6tc9, PDBj:6tc9
• PDBsum: 6tc9
• PubMed: 32598485
• UniProt: I4E596