Structure of PDB 6rkw Chain C Binding Site BS02

Receptor Information
>6rkw Chain C (length=828) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGN
DWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQG
NFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPD
VMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEG
LMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRE
TIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEV
KRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRH
RREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAK
TALVANPWQLGNVAAAGDDAARPEWLEPEFGVGLYYLTEQQAQAILDLRL
QKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQF
GDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRG
GKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRG
ARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEF
NRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRA
MGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPT
KSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEIS
IVGRNTQGVILIRTAEDENVVGLQRVAE
Ligand information
>6rkw Chain H (length=62) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gtacctacggcttatgattcttctcgcttccggcggcatcgggatgcccg
cgttgcaggcca
Receptor-Ligand Complex Structure
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PDB6rkw Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Resolution6.6 Å
Binding residue
(original residue number in PDB)		I174 V176 K671 N717 R722 I724 R725 L726 E728 A767 K775 R779 N818 T819 Q820
Binding residue
(residue number reindexed from 1)		I167 V169 K658 N704 R709 I711 R712 L713 E715 A754 K762 R766 N805 T806 Q807
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0034335 DNA negative supercoiling activity
GO:0042802 identical protein binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006351 DNA-templated transcription
GO:0009410 response to xenobiotic stimulus
GO:0046677 response to antibiotic
GO:0051276 chromosome organization
GO:2000104 negative regulation of DNA-templated DNA replication
Cellular Component
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rkw, PDBe:6rkw, PDBj:6rkw
PDBsum6rkw
PubMed31666516
UniProtP0AES4|GYRA_ECOLI DNA gyrase subunit A (Gene Name=gyrA)

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