Structure of PDB 6rja Chain C Binding Site BS02

Receptor Information
>6rja Chain C (length=815) Species: 322159 (Streptococcus thermophilus LMD-9) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQG
RRLTRRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSN
EELFIALKNMVKHRGISYLDGDYAQIVKENSKQLETKTPGQIQLERYQTY
GQLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFI
NRYLEILTGKRKYYHGPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFY
PDEFRAAKASYTAQEFNLLNDLNNSKEQKNQIINYVKNEKAMGPAKLFKY
IAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETL
DKLAYVLTLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSSIFGK
GWHNFSVKLMMELIPELYETSEEQMTILTRLGKTKYIDEKLLTEEIYNPV
VAKSVRQAIKIVNAAIKEYGDFDNIVIESRVVLNALQEHFRAHKIDTKVS
VHHHAVDALIIAASSDSILFSYQVDSKFNRKISDATIYATRQAKVGKDKA
DETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQTFEKVIEPIL
ENPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDSKLGNHIDITPKDSNNK
VVLQSVSPWRADVYFNKTTGKYEILGLKYADLQFEKGTGTYKISQEKYND
IKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQLFRFLSRTMPKQKHYV
ELKPYDKQKFEGGEALIKVLGNVANSGQCKKGLGKSNISIYKVRTDVLGN
QHIIKNEGDKPKLDF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rja Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y120 Y225 F252 R267 N286 K335 E445 M447 Y478
Binding residue
(residue number reindexed from 1)		Y118 Y213 F240 R255 N274 K313 E423 M425 Y447
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6rja, PDBe:6rja, PDBj:6rja
PDBsum6rja
PubMed31604602
UniProtQ03LF7|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

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