Structure of PDB 6rj9 Chain C Binding Site BS02

Receptor Information
>6rj9 Chain C (length=836) Species: 322159 (Streptococcus thermophilus LMD-9) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQG
RRLTRRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSN
EELFIALKNMVKHRGISYLDDYAQIVKENSKQLETKTPGQIQLERYQTYG
QLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFIN
RYLEILTGKRKYYHGPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFYP
DEFRAAKASYTAQEFNLLNDLNNLTVPKKLSKEQKNQIINYVKNEKAMGP
AKLFKYIAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQ
MDRETLDKLAYVLTLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKAN
SSIFGKGWHNFSVKLMMELIPELYETSEEQMTILTRLGKQKTKYIDEKLL
TEEIYNPVVAKSVRQAIKIVNAAIKEYGDFDNIVIEASRVVLNALQEHFR
AHKIDTKVSVVRGQFTSQLRRHWGHHHAVDALIIAASSILFSYQVDSKFN
RKISDATIYATRQAKVGKDKADETYVLGKIKDIYTQDGYDAFMKIYKKDK
SKFLMYRHDPQTFEKVIEPILENPFLKYKEEHGYIRKYSKKGNGPEIKSL
KYYDSKLGNHIDITPKDSNNKVVLQSVSPWRADVYFNKTTGKYEILGLKY
ADLQFEKGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTE
TKEQQLFRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQC
KKGLGKSNISIYKVRTDVLGNQHIIKNEGDKPKLDF
Ligand information
Receptor-Ligand Complex Structure
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PDB6rj9 Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Y225 R267 N286 I339 E445 M447 Y478
Binding residue
(residue number reindexed from 1)		Y212 R254 N273 I323 E429 M431 Y455
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6rj9, PDBe:6rj9, PDBj:6rj9
PDBsum6rj9
PubMed31604602
UniProtQ03LF7|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

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