Structure of PDB 6r8y Chain C Binding Site BS02

Receptor Information
>6r8y Chain C (length=117) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYL
TAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVL
PNIQAVLLPKKTESHHK
Ligand information
>6r8y Chain J (length=144) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagattctaccaaaagtgtatttggaaactgctcc
atcaaaaggcatgttcagctgaaccagctgaacatgccttttgaugagca
gtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB6r8y DNA damage detection in nucleosomes involves DNA register shifting.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R12 R30 R43 V44 G45 K76 T77 R78
Binding residue
(residue number reindexed from 1)		R3 R21 R34 V35 G36 K67 T68 R69
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Biological Process
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Cellular Component
External links
PDB RCSB:6r8y, PDBe:6r8y, PDBj:6r8y
PDBsum6r8y
PubMed31142837
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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