Structure of PDB 6r1r Chain C Binding Site BS02

Receptor Information
>6r1r Chain C (length=738) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFY
DGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPP
ALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQ
LEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAV
STFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQ
RAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG
AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKG
EDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLDIALPTKPLN
DVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPI
PAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYY
LLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE
ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDG
ILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYD
PSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGA
Ligand information
Receptor-Ligand Complex Structure
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PDB6r1r A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E111 L120
Binding residue
(residue number reindexed from 1)		E111 L120
Enzymatic activity
Catalytic site (original residue number in PDB) C225 N437 C439 D441 C462 Y730 Y731
Catalytic site (residue number reindexed from 1) C225 N437 C439 D441 C462 Y730 Y731
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0044183 protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0009265 2'-deoxyribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
Cellular Component
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r1r, PDBe:6r1r, PDBj:6r1r
PDBsum6r1r
PubMed9395490
UniProtP00452|RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha (Gene Name=nrdA)

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