Structure of PDB 6o96 Chain C Binding Site BS02

Receptor Information
>6o96 Chain C (length=107) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAE
ILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNI
QSVLLPK
Ligand information
>6o96 Chain J (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggagaatccgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgggattctcga
Receptor-Ligand Complex Structure
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PDB6o96 Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K15 R17 R20 R32 R77
Binding residue
(residue number reindexed from 1)		K4 R6 R9 R21 R66
Binding affinityPDBbind-CN: Kd=50nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6o96, PDBe:6o96, PDBj:6o96
PDBsum6o96
PubMed30981630
UniProtP06897|H2A1_XENLA Histone H2A type 1

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