Structure of PDB 6mxc Chain C Binding Site BS02

Receptor Information

>6mxc Chain C (length=220) Species: 185431 (Trypanosoma brucei brucei TREU927)

KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKT
LKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPN
VVDFIRITSYGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIR
REYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYR
NYRHVFVLKPEYAKRYPSKL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6mxc Chain C Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6mxc Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.
• Resolution: 1.993 Å
• Binding residue (original residue number in PDB): V85 G88 S89 E147 D148
• Binding residue (residue number reindexed from 1): V78 G81 S82 E133 D134
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E147 D148 D151 Y201 R214
• Catalytic site (residue number reindexed from 1): E133 D134 D137 Y187 R200

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0000310 xanthine phosphoribosyltransferase activity
• GO:0004422 hypoxanthine phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0042301 phosphate ion binding
• GO:0046872 metal ion binding
• GO:0052657 guanine phosphoribosyltransferase activity

Biological Process

• GO:0006178 guanine salvage
• GO:0032263 GMP salvage
• GO:0032264 IMP salvage
• GO:0046100 hypoxanthine metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0020015 glycosome

External links

• PDB: RCSB:6mxc, PDBe:6mxc, PDBj:6mxc
• PDBsum: 6mxc
• PubMed: 31287615
• UniProt: Q38CA1