Structure of PDB 6m2d Chain C Binding Site BS02

Receptor Information

>6m2d Chain C (length=57) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPKKCPICRQAITR
VIPLYNS

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

6m2d Chain C Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6m2d MUL1-RING recruits the substrate, p53-TAD as a complex with UBE2D2-UB conjugate.
Resolution	1.795 Å
Binding residue (original residue number in PDB)	C317 H319 C336 C339
Binding residue (residue number reindexed from 1)	C22 H24 C41 C44
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

External links

PDB	RCSB:6m2d, PDBe:6m2d, PDBj:6m2d
PDBsum	6m2d
PubMed	35048531
UniProt	Q969V5\|MUL1_HUMAN Mitochondrial ubiquitin ligase activator of NFKB 1 (Gene Name=MUL1)

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