Structure of PDB 6koq Chain C Binding Site BS02

Receptor Information
>6koq Chain C (length=1138) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAE
RGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKD
MTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVV
SQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRI
DRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLD
IYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGE
PITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNR
RLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAA
IKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVH
PSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSD
EIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEV
DYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLV
GTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFA
RSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPW
EGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNI
SDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFG
EKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQK
RKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRM
NIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPV
FDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVG
YMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAM
QAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLK
ELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6koq RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Resolution3.353 Å
Binding residue
(original residue number in PDB)		N163 G426 F433 G1053 Q1060 R1061 M1065
Binding residue
(residue number reindexed from 1)		N143 G406 F413 G1033 Q1040 R1041 M1045
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6koq, PDBe:6koq, PDBj:6koq
PDBsum6koq
PubMed32127479
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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