Structure of PDB 6kon Chain C Binding Site BS02

Receptor Information
>6kon Chain C (length=1092) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAE
RGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKD
MTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVV
SQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFVRIDRKRRQPVT
VLLFSEIMRSTKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFK
EKRYDLARVGRYKVNKKLGLHTEEDVVATIEYLVRLHEGQTTMTVPGGVE
VPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAI
TPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGG
LSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFI
ETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVR
RKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQ
RQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMH
DNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGE
MALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDT
KLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGET
ELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELP
AGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTP
VDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDE
LLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFD
GRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQ
FGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENI
PEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELRLERAAA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kon RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R224 F433 E460 G1053 R1061 M1065
Binding residue
(residue number reindexed from 1)		R195 F377 E404 G997 R1005 M1009
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kon, PDBe:6kon, PDBj:6kon
PDBsum6kon
PubMed32127479
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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