Structure of PDB 6jr8 Chain C Binding Site BS02

Receptor Information
>6jr8 Chain C (length=812) Species: 376686 (Flavobacterium johnsoniae UW101) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQYLGNCTAYSVKGNKVVFSCANNSKIMLQLCSGEVVKIWASADGNFVRN
NESFAVIEEDLGWKGNVTVKEEPSTYEIFTEQLRIRVNKAPFQLQIFDKY
QKLLFSDYAEKGFVNDNGKIRTNKVLRNDEQFFGLGEKSGNLNRRGSAYK
MWNSDQPCYGVNEDPLYKSIPFFMSSYRYGIFFDNTYKTEFKFGSESNDY
YSFEAPAGQMVYYFMFGNDYKEIIQNYIALTGKPIMPPKWALGFSQCRGD
YTREDQAREIAAEFRKRKIPCDIIYQDIGWTEGLQDFDWRKNNYNNPKGM
VKDLSDMGFKMIVSQDPVISQANQQQWKEADALGHLVKDVRTGKSYDMPW
PWGGNCGVVDFTKPEVADWWGSYQQKPLNDGVRGFWTAMGEPAWSNEDAV
DRLNMKHHLGMHNEIHNVYGFTWDKVVTEQFYKHNPNKRIFQMTRAAYAG
LQRYTFGWSGDSGNGSNVLDGWKQMANQIPVGLSAGMGLIPFWTCDISGY
CGDIKDYDAMAELYVRWLQFGVFTPLSRAHHEGGNAVEPWKFGTEAENIS
RKSIELKYKLFPYLYTYAREAHDTGLPIMRALLLEYPNDKETFKLNGQFL
VGKELLVAPVVEQGAVTKDVYLPEGEWIDFNNCKTKYKGEQWITVDAPLN
TIPVFVKKGSIIPQMPVMQYIDEKKVYPVTFDIFPGNLNKETSFTFYEDD
GESRDYERDVFCKTKITSKASNEEIKITVGEREYKGYSPAGPRNFILKIH
ASNKPKDVFAGGEKLKNVKPHVLEKNIEADFTKINWSWNEAENVISVRIP
DSGKNAVITIKN
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain6jr8 Chain G Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6jr8 Structural insights into polysaccharide recognition by Flavobacterium johnsoniae dextranase, a member of glycoside hydrolase family 31.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		G273 I302 W376 Y524 E556 G557
Binding residue
(residue number reindexed from 1)		G249 I278 W352 Y500 E532 G533
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.20: alpha-glucosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558 alpha-1,4-glucosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6jr8, PDBe:6jr8, PDBj:6jr8
PDBsum6jr8
PubMed31552702
UniProtA5FBI1

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