Structure of PDB 6jmt Chain C Binding Site BS02

Receptor Information
>6jmt Chain C (length=339) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAW
PPTLLQMVETLYNNGANSIWEHSLLDPASRKANPQDKVHPNKAEFIRAKY
QMLAFVHRLPCRESVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH
PEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHH
ELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADAALDLSELA
KAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVPFLPV
NPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6jmt Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6jmt GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C11 C14 C31 C34
Binding residue
(residue number reindexed from 1)		C5 C8 C25 C28
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
Biological Process
GO:0007420 brain development
GO:0032012 regulation of ARF protein signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6jmt, PDBe:6jmt, PDBj:6jmt
PDBsum6jmt
PubMed32780989
UniProtQ9JLQ2|GIT2_MOUSE ARF GTPase-activating protein GIT2 (Gene Name=Git2)

[Back to BioLiP]