Structure of PDB 6jcy Chain C Binding Site BS02

Receptor Information
>6jcy Chain C (length=1139) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRE
SAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDEC
KDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTE
RVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTV
GVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDE
ALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGL
HVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDH
FGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRP
VVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEV
RDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDG
VVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVP
SSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSE
APLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRM
RKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVA
IMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRD
IPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLR
AIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVY
VAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGV
PRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIV
STPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYP
VTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEME
CWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFK
VLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAAN
Ligand information
Receptor-Ligand Complex Structure
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PDB6jcy Structures and mechanism of transcription initiation by bacterial ECF factors.
Resolution3.106 Å
Binding residue
(original residue number in PDB)		G1059 A1061 R1067 M1071
Binding residue
(residue number reindexed from 1)		G1037 A1039 R1045 M1049
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6jcy, PDBe:6jcy, PDBj:6jcy
PDBsum6jcy
PubMed31131408
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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