Structure of PDB 6ica Chain C Binding Site BS02

Receptor Information

>6ica Chain C (length=378) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPVHEQLQVPQCLAAKITVPHKILAENKEFKIIDVLSSDVETLTILADKV
SCGHFVNVSHKLTGTLAANQQQSAQKLLQKKLVKPFGVSKLHKDVYEIKH
EEEVNAALKEIVSDNIWQTLTHMTSYYNRSATKDTGVDTANWLKSKFEQM
AVEYGRTDTSTFFVKTGWYKQPSLVTVIGKDIKAPAIVIGAHMDTLDGRM
PGAGDDGSGSSSIMEAARVILSSKTTFKRPIYFIWYAAEERGLVGSQHVV
QHFQEQSIPVKAVVQFDMTGYRNDANDPTMWVFTDYTDRDLSNYLAKLID
HYIHVPVDYSRCGYGCSDHASWNEEDIPAAFPCETSFADHNPYIHTSSDK
MDLLNLEHMTNFSKLAVAFAIELASELE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6ica Chain C Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6ica The crystal structure of Legionella pneumophila LapA aminopeptidase
Resolution	2.195 Å
Binding residue (original residue number in PDB)	D251 E286 H391
Binding residue (residue number reindexed from 1)	D205 E240 H345
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H238 D251 E285 E286 D313 H391
Catalytic site (residue number reindexed from 1)	H192 D205 E239 E240 D267 H345
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0004177	aminopeptidase activity
GO:0008235	metalloexopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

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Biological Process

External links

PDB	RCSB:6ica, PDBe:6ica, PDBj:6ica
PDBsum	6ica
PubMed
UniProt	Q5ZRR6

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