Structure of PDB 6exh Chain C Binding Site BS02

Receptor Information
>6exh Chain C (length=353) Species: 239 (Flavobacterium sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSLTLEIPTSPLIIKITQQERNILSNVGNLLVKAFGNYENPDYIASLHLH
AFQLLPERITRILSQFGSDFSAEQYGAIVFQGLIEVDQDDLGPTPPNWQG
ADYGKLNKYGFICSLLHGAVPSKPVQYYAQRKGGGLLHAVIPDEKMAATQ
TGSGSKTDLFVHTEDAFLSNQADFLSFLYLRNEERVPSTLYSIRSHGKMN
PVMKKLFEPIYQCPKDANYANSGPTASVLYGNRELPFIRFDAAEQIFNEN
AGQTSEALGNLMDFWDEAKTLINSDYIPNSGDLIFVNNHLCAHGRSAFIA
GQRIENGEIIKCERRQMLRMMSKTSLIHIRSVTRTDDPYFIMEEHLGKIF
DLD
Ligand information
Ligand IDLYO
InChIInChI=1S/C6H14N2O3/c7-2-1-4(9)3-5(8)6(10)11/h4-5,9H,1-3,7-8H2,(H,10,11)/t4-,5-/m0/s1
InChIKeyASYBZHICIMVQII-WHFBIAKZSA-N
SMILES
SoftwareSMILES
CACTVS 3.370NCC[C@H](O)C[C@H](N)C(O)=O
CACTVS 3.370NCC[CH](O)C[CH](N)C(O)=O
OpenEye OEToolkits 1.7.0C(CN)C(CC(C(=O)O)N)O
ACDLabs 12.01O=C(O)C(N)CC(O)CCN
OpenEye OEToolkits 1.7.0C(CN)C(C[C@@H](C(=O)O)N)O
FormulaC6 H14 N2 O3
Name4-HYDROXY-LYSINE
ChEMBL
DrugBank
ZINCZINC000013511406
PDB chain6exh Chain C Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6exh Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q144 Q164 T165 G166 H176 N232 R338
Binding residue
(residue number reindexed from 1)		Q130 Q150 T151 G152 H162 N218 R319
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:6exh, PDBe:6exh, PDBj:6exh
PDBsum6exh
PubMed30410048
UniProtJ3BZS6|LYS4O_FLASC L-lysine 4-hydroxylase (Gene Name=PMI10_03368)

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