Structure of PDB 6erh Chain C Binding Site BS02

Receptor Information
>6erh Chain C (length=493) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRDSLIFLVDASKAMFESQDELTPFDMSIQCIQSVYISKIISSDRDLLAV
VFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMM
GHGSDYSLSEVLWVCANLFSDVQMSHKRIMLFTNEDNPHGNDSAKASRAR
TKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAERVHFEESSKLED
LLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRE
TNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFD
DPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLE
KEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFAD
DKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLE
ALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDY
Ligand information
Receptor-Ligand Complex Structure
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PDB6erh XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R80 R254 L256 Q278 R363 R403
Binding residue
(residue number reindexed from 1)		R45 R213 L215 Q237 R322 R362
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6erh, PDBe:6erh, PDBj:6erh
PDBsum6erh
PubMed30291363
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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