Structure of PDB 6djn Chain C Binding Site BS02

Receptor Information

>6djn Chain C (length=372) Species: 9031 (Gallus gallus)

ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSY
VGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPT
LLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVL
DSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTT
AEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNE
RFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGT
TMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQ
QMWITKQEYDEAGPSIVHRKCF

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 6djn Chain C Residue 803

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6djn Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): Q137 G156 D157 G158 V159
• Binding residue (residue number reindexed from 1): Q134 G153 D154 G155 V156
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0030240 skeletal muscle thin filament assembly
• GO:0048741 skeletal muscle fiber development

Cellular Component

• GO:0001725 stress fiber
• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005865 striated muscle thin filament
• GO:0005884 actin filament

External links

• PDB: RCSB:6djn, PDBe:6djn, PDBj:6djn
• PDBsum: 6djn
• PubMed: 30760599
• UniProt: P68139|ACTS_CHICK Actin, alpha skeletal muscle (Gene Name=ACTA1)