Structure of PDB 6co7 Chain C Binding Site BS02

Receptor Information
>6co7 Chain C (length=1061) Species: 45351 (Nematostella vectensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTPLYDGGDSSHVHLNKFSRRECIRFVPKCTTKHPTNAYGEIDFEGYGGQ
KRAPYLRMSHDTDANLVITLMLKRWNLEIPNLVISVTGGAKSFVLKPRLR
EMFRRGLIKAAKTTGAWIITGGTNTGVMKHVGEAVKEQQLMFGSDTQVNV
IGIATWGIVDKQSDLISEKNGKYPALYSMEPTPGHQGAMLDPNHSHFFLV
DDGTEGKYGVEIGMRSRIEEAIMKVKTDSRSEAGSIGVPVVLLVLEGGPN
TVATMYELIKKKVPAVVIDGSGRAASVVGFAYNHTIKRNVDGQTINVIDP
QYEDEVRAKVVEVFGAKGADKTYSMIKDVLEDEKMISVYSLDGEISQDID
LAILKALLKANRSSPVAQLNLALAWNRIDLAKSDIFTEEQQWTTETLSAA
MLTALLDDKAEFAELFLQNGLSMREFLSLDILCKLYAEVPGNTTIKPLLQ
KEMGKRQVKTIDMDVVGEVIEELMGDMFESYYRKDGHYFGIDPLPTPYLD
VFLWAVLCNRRELARVLWEAGREPMAAALMASRLLKRMASRAQEDNTITD
ISSDLYDHARLFEERAVGVLDECFNENETLSQTLLVRELDHYSRMTALEL
AVSAESQDFIAHTSCQVLLTRLWMGTMAMNTRWWKVLVCLYLPVLIFPII
YFVPDEQHERQAAEREHQKSLNQDDSMEVIMRNKKLGFCDRIMHFYSAPF
SKFVGNVVGYLAFIFLYAYVVLFNFPRFDPAKTLGGIHPTEIVLYFWVFT
ILIEEIRQLAAKPPKYIKDKVSVYFSDTWNFVDIFSLTVFIIAIILRFFT
NSRIFTASRIILSLDIIFFIVRSLQIFSVNRLLGPKLVMIQKMMQDLAQF
IIILAVFTIAYGIALHAVMFPSPGIYARNNTWVTITSVVQYPYWQMYGEL
FLDEIQGEKPKEFGEVDPDGRWLSPLLLAIYMVFTNILLLNLLIAIFNYT
FERVQEDSDKVWKFQRYDLVQEYHSRPVFAPPLVLLGHILIFIRWVWRTM
KIGLSPAEMEQMDNWEFQAAEMYIHQQQQKNSGTLEERVRALGDRVDCIN
SQLNRVLDSMS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6co7 Chain C Residue 4000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6co7 Structure of a TRPM2 channel in complex with Ca2+explains unique gating regulation.
Resolution3.07 Å
Binding residue
(original residue number in PDB)		E893 Q896 N918 D921
Binding residue
(residue number reindexed from 1)		E755 Q758 N780 D783
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0015280 ligand-gated sodium channel activity
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0019722 calcium-mediated signaling
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6co7, PDBe:6co7, PDBj:6co7
PDBsum6co7
PubMed29745897
UniProtA7T1N0|TMP2L_NEMVE Transient receptor potential cation channel subfamily M member-like 2 (Gene Name=TRPM2)

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