Structure of PDB 5ysu Chain C Binding Site BS02

Receptor Information
>5ysu Chain C (length=1017) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQ
KADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMII
SMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSV
NVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQ
VLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTR
AITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKA
TYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQ
LSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMV
RPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEI
MISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLL
GLCEQKRGKDNKAVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHE
THEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADL
QPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTAN
PTLLLDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVS
SMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKV
LVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQS
VFECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFV
DAICWAFKHNNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFV
SETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTS
NQVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFL
VQIKEVGGDPTDYLFAE
Ligand information
Ligand IDF2X
InChIInChI=1S/C11H10O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-4,6,12H,5H2,1H3/t6-/m1/s1
InChIKeyALPCEXCHMFUSAN-ZCFIWIBFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC1CC(=O)c2c(cccc2O)C1=O
OpenEye OEToolkits 2.0.7C[C@@H]1CC(=O)c2c(cccc2O)C1=O
CACTVS 3.385C[C@@H]1CC(=O)c2c(O)cccc2C1=O
CACTVS 3.385C[CH]1CC(=O)c2c(O)cccc2C1=O
FormulaC11 H10 O3
Name(2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione
ChEMBL
DrugBank
ZINC
PDB chain5ysu Chain C Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ysu RanL182A in complex with RanBP1-CRM1
Resolution2.3 Å
Binding residue
(original residue number in PDB)		S145 V149 C152 L209
Binding residue
(residue number reindexed from 1)		S146 V150 C153 L210
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ysu, PDBe:5ysu, PDBj:5ysu
PDBsum5ysu
PubMed
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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