Structure of PDB 5yew Chain C Binding Site BS02

Receptor Information
>5yew Chain C (length=389) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLV
EMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGI
GHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAG
CLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLV
ANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQ
HMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKALAEGFHARL
QEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAED
LPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPS
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain5yew Chain C Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yew Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
Resolution3.2 Å
Binding residue
(original residue number in PDB)		T84 K88 H107 G181
Binding residue
(residue number reindexed from 1)		T79 K83 H102 G176
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008053 mitochondrial fusion
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5yew, PDBe:5yew, PDBj:5yew
PDBsum5yew
PubMed29483649
UniProtQ8IWA4|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

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