Structure of PDB 5xox Chain C Binding Site BS02

Receptor Information

>5xox Chain C (length=229) Species: 559292 (Saccharomyces cerevisiae S288C)

KFGYVRQFETHDVILPQCYIVVRIDGKKFHEFSKFYEFAKPNDENALKLM
NACAKNLVLKYKNDIILAFGESDEYSFILKSSTTLFNRRKDKLATLFGSF
FTSNYVALWAKFFPEKPLNIKHLPYFDSRCVAYPNLQTIKDYLSWRYVDT
HINNLYNTTFWQLIIKCGLTPQESEKKLCGTFSNEKQEILFSECGINYNN
EPEMFKKGSLVTRKGEILHINVIAQIDEL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5xox Chain C Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5xox Crystal structure of tRNA(His) guanylyltransferase from Saccharomyces cerevisiae
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): D29 G30
• Binding residue (residue number reindexed from 1): D25 G26
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.79: tRNA(His) guanylyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0005525 GTP binding
• GO:0008193 tRNA guanylyltransferase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0097748 3'-5' RNA polymerase activity

Biological Process

• GO:0006400 tRNA modification
• GO:0008033 tRNA processing
• GO:0099116 tRNA 5'-end processing

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:5xox, PDBe:5xox, PDBj:5xox
• PDBsum: 5xox
• PubMed: 28623126
• UniProt: P53215|THG1_YEAST tRNA(His) guanylyltransferase (Gene Name=THG1)