Structure of PDB 5w6q Chain C Binding Site BS02

Receptor Information
>5w6q Chain C (length=521) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLK
EARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGG
EWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHVEA
TGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFD
ELGLPAIGKTEKTGKRSTSAAVLEALREAHAIVEKILQYRELTKLKSTYI
DPLPELIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRR
AFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKT
LEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADL
MKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGV
YPLAVPLEVEVGIGEDWLSAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5w6q Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S543 T544 T569 T571 R573 S575 S576 S577 D578 N580 F667 Y671 M673 S674 R677 R728 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N187 N189 S190 S247 T248 T273 T275 R277 S279 S280 S281 D282 N284 F357 Y361 M363 S364 R367 R418 M437 N440 Q444
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5w6q, PDBe:5w6q, PDBj:5w6q
PDBsum5w6q
PubMed29986111
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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