Structure of PDB 5vx2 Chain C Binding Site BS02

Receptor Information
>5vx2 Chain C (length=150) Species: 9606,10090 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
Ligand information
>5vx2 Chain D (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DMRPEIRIAQELRRIGDEFNATYAR
Receptor-Ligand Complex Structure
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PDB5vx2 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Resolution1.851 Å
Binding residue
(original residue number in PDB)		V216 H224 A227 M231 L235 R248 V249 H252 V253 D256 N260 G262 R263 V265 F318 F319
Binding residue
(residue number reindexed from 1)		V45 H53 A56 M60 L64 R77 V78 H81 V82 D85 N89 G91 R92 V94 F147 F148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5vx2, PDBe:5vx2, PDBj:5vx2
PDBsum5vx2
PubMed29149594
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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