Structure of PDB 5vie Chain C Binding Site BS02

Receptor Information

>5vie Chain C (length=667) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT
FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSG
NIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIV
ADQLELPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHP
KDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPD
DGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGA
RNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKL
AYMPHTFFIGDHANMFPHLKKKAVIDFIYDNRIVLNGIDLKAFLDSLPDV
KIVNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAAT
GEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVP
NSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLAD
VCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELI
AKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERL
YLQMWEHYAANKPDHMI

Ligand information

>5vie Chain D (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YPGGSTPVSSAN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5vie Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	H496 H498 H499 N557 H558 P559 Y632 T633 K634 V895 P897
Binding residue (residue number reindexed from 1)	H160 H162 H163 N221 H222 P223 Y296 T297 K298 V536 P538

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:5vie, PDBe:5vie, PDBj:5vie
PDBsum	5vie
PubMed	29058723
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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