Structure of PDB 5txp Chain C Binding Site BS02

Receptor Information

>5txp Chain C (length=556) Species: 11678 (Human immunodeficiency virus type 1 BH10)

MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKIS
KIGPENPYNTPVFVIKKKDSTKWRKLIDLRELNKRTQDFWEVQLGIPHPA
GLKKKKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNV
LPMGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQH
RTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPE
KDSWTVNDICKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEE
AELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKN
LKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETW
ETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANR
ETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTN
SQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQV
DKLVSA

Ligand information

>5txp Chain F (length=20)

cagtccctgttcgggcgccg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5txp Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Y183 M184 M230 G231 N255 C258 G262 W266 H361 R448 K451 T473 Q475 Y501
• Binding residue (residue number reindexed from 1): Y185 M186 M232 G233 N257 C260 G264 W268 H363 R450 K453 T475 Q477 Y503

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:5txp, PDBe:5txp, PDBj:5txp
• PDBsum: 5txp
• PubMed: 28396546
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)