Structure of PDB 5nsq Chain C Binding Site BS02

Receptor Information

>5nsq Chain C (length=518) Species: 185431 (Trypanosoma brucei brucei TREU927)

LPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTH
KQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVV
VGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPI
AAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVA
TSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGY
GGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPA
DYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRN
DDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLT
GAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEF
KSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNS
NGATGFGPALLTEYFRKL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5nsq Chain C Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5nsq Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): D294 D371 E373
• Binding residue (residue number reindexed from 1): D291 D368 E370
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): K301 R375
• Catalytic site (residue number reindexed from 1): K298 R372

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0005515 protein binding
• GO:0008233 peptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5nsq, PDBe:5nsq, PDBj:5nsq
• PDBsum: 5nsq
• PubMed: 28815215
• UniProt: Q385B0