Structure of PDB 5n6n Chain C Binding Site BS02

Receptor Information
>5n6n Chain C (length=698) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPFSNAEVYYGNRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQ
GNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYK
HINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQ
FWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQAS
QMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLI
GYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYG
KILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASI
KEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPFKQLYN
DGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYE
IDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESG
FFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGG
LAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRL
AYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAAT
EGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain5n6n Chain D Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5n6n Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		F303 D478 Q623
Binding residue
(residue number reindexed from 1)		F261 D425 Q570
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.1.28: alpha,alpha-trehalase.
Gene Ontology
Molecular Function
GO:0004555 alpha,alpha-trehalase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015927 trehalase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0071465 cellular response to desiccation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n6n, PDBe:5n6n, PDBj:5n6n
PDBsum5n6n
PubMed29087344
UniProtP32356|TREA_YEAST Cytosolic neutral trehalase (Gene Name=NTH1)

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