Structure of PDB 5mkm Chain C Binding Site BS02

Receptor Information
>5mkm Chain C (length=275) Species: 35619 (Streptomyces griseoflavus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAAPAGGEVRRVTMYAERLAGGQMGYGLEKGKASIPGPLIELNEGDTLHV
EFENTMDVPVSLHVHGLDYEISSDGTKQNKSHVEPGGTRTYTWRTHEPGR
RADGTWRAGSAGYWHYHDHVVGTEFGTGGIRNGLYGPVIVRRKGDVLPDA
THTIVFNDMTINNRPAHTGPNFEATVGDRVEIVMITHGEYYHTFHMHGHR
WADNRTGMLTGPDDPSQVIDNKICGPADSFGFQIIAGEGVGAGAWMYHCH
VQSHSDMGMVGLFLVKKPDGTIPGY
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain5mkm Chain C Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mkm Investigations of Accessibility of T2/T3 Copper Center of Two-Domain Laccase fromStreptomyces griseoflavusAc-993.
Resolution1.996 Å
Binding residue
(original residue number in PDB)		H103 H105 H157
Binding residue
(residue number reindexed from 1)		H63 H65 H117
Annotation score1
Enzymatic activity
Enzyme Commision number 1.10.3.2: laccase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052716 hydroquinone:oxygen oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5mkm, PDBe:5mkm, PDBj:5mkm
PDBsum5mkm
PubMed31261802
UniProtA0A0M4FJ81

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