Structure of PDB 5mk0 Chain C Binding Site BS02
Receptor Information
>5mk0 Chain C (length=359) Species:
9606
(Homo sapiens) [
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AVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLR
QNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSG
KSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAG
AFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFL
VARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVA
HLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTM
DVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVT
GPDIFAKLV
Ligand information
>5mk0 Chain D (length=13) Species:
9606
(Homo sapiens) [
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VSDLDKLLDDFEQ
Receptor-Ligand Complex Structure
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PDB
5mk0
Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Resolution
1.765 Å
Binding residue
(original residue number in PDB)
E137 K141 T145 K192 R198 K199 L202 L338
Binding residue
(residue number reindexed from 1)
E135 K139 T143 K190 R196 K197 L200 L336
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0071985
multivesicular body sorting pathway
View graph for
Biological Process
External links
PDB
RCSB:5mk0
,
PDBe:5mk0
,
PDBj:5mk0
PDBsum
5mk0
PubMed
28602823
UniProt
Q9H3S7
|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)
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