Structure of PDB 5mk0 Chain C Binding Site BS02

Receptor Information
>5mk0 Chain C (length=359) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLR
QNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSG
KSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAG
AFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFL
VARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVA
HLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTM
DVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVT
GPDIFAKLV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mk0 Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Resolution1.765 Å
Binding residue
(original residue number in PDB)
E137 K141 T145 K192 R198 K199 L202 L338
Binding residue
(residue number reindexed from 1)
E135 K139 T143 K190 R196 K197 L200 L336
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mk0, PDBe:5mk0, PDBj:5mk0
PDBsum5mk0
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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