Structure of PDB 5hjo Chain C Binding Site BS02

Receptor Information
>5hjo Chain C (length=854) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDRSNFKTCDESSFCKRQRSIRPGLSPYRALLDTLQLGPDALTVHLIHEV
TKVLLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTARLSVSG
RDDNSVELTVAEGPYKIILTAQPFRLDLLEDRSLLLSVNARGLMAFEHQR
AEPGAWEETFKTHSDSKPYGPTSVGLDFSLPGMEHVYGIPEHADSLRLKV
TEGGEPYRLYNLDVFQYELNNPMALYGSVPVLLAHSFHRDLGIFWLNAAE
TWVDISSNPQTDIRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPP
LFSLGYHQSRWNYRDEADVLEVDQGFDDHNMPCDVIWLDIEHADGKRYFT
WDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELRNHGLYV
KTRDGSDYEGWCWPGSASYPDFTNPRMRAWWSNMFSFDNYEGSAPNLYVW
NDMNEPSVFNGPEVTMLKDAVHYGGWEHRDIHNIYGLYVHMATADGLIQR
SGGIERPFVLSRAFFSGSQRFGAVWTGDNTAEWDHLKISIPMCLSLALVG
LSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLA
SQYQDAIRDALFQRYSLLPFWYTLFYQAHKEGFPVMRPLWVQYPEDMSTF
SIEDQFMLGDALLIHPVSDAGAHGVQVYLPGQEEVWYDIQSYQKHHGPQT
LYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSPQGTA
QGELFLDDGHTFNYQTRHEFLLRRFSFSGSTLVSSSADPKGHLETPIWIE
RVVIMGAGKPAAVVLQTKGSPESRLSFQHDPETSVLILRKPGVSVASDWS
IHLR
Ligand information
Ligand IDZ61
InChIInChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5+,6+/m1/s1
InChIKeyPMMURAAUARKVCB-ZXXMMSQZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C1C(C(C(OC1O)CO)O)O
OpenEye OEToolkits 1.7.6C1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O
ACDLabs 12.01OC1C(OC(O)CC1O)CO
CACTVS 3.370OC[CH]1O[CH](O)C[CH](O)[CH]1O
CACTVS 3.370OC[C@H]1O[C@H](O)C[C@@H](O)[C@@H]1O
FormulaC6 H12 O5
Name2-deoxy-alpha-D-arabino-hexopyranose;
2-deoxy-alpha-D-glucopyranose;
2-deoxy-alpha-D-mannopyranose
ChEMBLCHEMBL4303562
DrugBank
ZINCZINC000003860328
PDB chain5hjo Chain H Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hjo Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		W423 D451 I452 W562 D564 R624 D640 F673 H698
Binding residue
(residue number reindexed from 1)		W311 D339 I340 W450 D452 R512 D528 F561 H586
Annotation score2
Enzymatic activity
Enzyme Commision number 3.2.1.207: mannosyl-oligosaccharide alpha-1,3-glucosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515 protein binding
GO:0015926 glucosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0033919 glucan 1,3-alpha-glucosidase activity
GO:0090599 alpha-glucosidase activity
GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006491 N-glycan processing
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0017177 glucosidase II complex
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hjo, PDBe:5hjo, PDBj:5hjo
PDBsum5hjo
PubMed27462106
UniProtQ8BHN3|GANAB_MOUSE Neutral alpha-glucosidase AB (Gene Name=Ganab)

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